Ductal Carcinoma in Situ: X-ray Fluorescence Microscopy and Dynamic Contrast-enhanced MR Imaging Reveals Gadolinium Uptake within Neoplastic Mammary Ducts in a Murine Model1

摘要

We used a transgenic mouse model of breast cancer to investigate contrast enhancement of ductal carcinoma in situ (DCIS) on clinical dynamic contrast material–enhanced (DCE) MR images of the breast, and we have shown via two independent routes—DCE MR imaging and x-ray fluorescence microscopy—that after injection of gadodiamide, there is gadolinium uptake inside ducts distended with murine DCIS.